In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran
نویسندگان
چکیده
منابع مشابه
The Mucosal Adjuvant Potential of Cross-Linked Dextran Microspheres as Dry Powder
Objective(s) The immunoadjuvant potential of cross-linked dextran microspheres (CDM) as absorption enhancer and Quillaja saponins (QS) as immunomodulator adjuvant was evaluated. Materials and Methods CDM loaded or tetanus-mixed toxoid (TT) or Quillaja saponin (QS) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum IgG and nasal lavage sIgA tite...
متن کاملIntracellular degradation of microspheres based on cross-linked dextran hydrogels or amphiphilic block copolymers: A comparative Raman microscopy study
Micro- and nanospheres composed of biodegradable polymers show promise as versatile devices for the controlled delivery of biopharmaceuticals. Whereas important properties such as drug release profiles, biocompatibility, and (bio)degradability have been determined for many types of biodegradable particles, information about particle degradation inside phagocytic cells is usually lacking. Here, ...
متن کاملMucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid
Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...
متن کاملMucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid
Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...
متن کاملthe mucosal adjuvant potential of cross-linked dextran microspheres as dry powder
objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2006
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm060385z